Methotrexate leukoencephalopathy
نویسندگان
چکیده
منابع مشابه
Methotrexate‐induced leukoencephalopathy presenting as stroke in the emergency department
Methotrexate-induced leukoencephalopathy is to be considered as a potential etiology in any patient presenting with stroke-like symptoms after receiving methotrexate. One of our cases suggests that the method of administration of the methotrexate can be IV or intrathecal and still results in leukoencephalopathy.
متن کاملAcute fever and delayed leukoencephalopathy following low dose intraventricular methotrexate.
Nine out of 14 patients treated with intraventricular methotrexate (MTX) for meningeal carcinomatosis from breast carcinoma and surviving more than 4 months developed disseminated necrotising leukoencephalopathy (DNL). All four patients who had received both intraventricular MTX and whole brain radiotherapy developed DNL. Five of the six patients who experienced an acute febrile reaction with m...
متن کاملMethotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.
PURPOSE Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on safety of intrathecal and high-dose MTX rechallenge in patients with neurotoxicity. PATIENTS AND M...
متن کاملPrevention of neurotoxicity by high-dose folinic acid rescue after high-dose methotrexate and intrathecal methotrexate without compromising cure inspite of previous transient leukoencephalopathy after intrathecal methotrexate.
Dear Editor, Methotrexate (MTX) is a frequently used chemotherapeutic agent in the treatment of childhood acute lymphoblastic leukaemia (ALL) and lymphoma. Besides oral and intravenous MTX, intrathecal MTX is an essential component of chemotherapy for ALL and is effective in preventing recurrences of central nervous system (CNS) leukaemia. Acute, subacute and chronic neurotoxicity have been obs...
متن کاملPrevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate.
BACKGROUND AND PURPOSE An effective treatment for acute lymphoblastic leukemia (ALL), intravenous (IV) methotrexate (MTX) has a notable toxic effect on the CNS, with leukoencephalopathy (LE) being the most common form. The purpose of this study was to use objective quantitative MR imaging to prospectively assess potential risk factors on the temporal evolution of LE in patients treated for ALL....
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ژورنال
عنوان ژورنال: Cancer Research, Statistics, and Treatment
سال: 2019
ISSN: 2590-3233
DOI: 10.4103/crst.crst_73_19